Tip:
Highlight text to annotate it
X
Listen! A long question...
How do you explain in an entertaining lighthearted elegant and clever way yet
with a scientific background and without going into excessive detail
the principles of purification of monoclonal antibodies by means of
Protein A Affinity Chromatography,
which is made possible exceptionally quickly simply
efficiently and in very high purity with the aid of TOYOPEARL chromatography
resins?
This is how it's done.
Once upon a time
there was a Tosoh TOYOPEARL.
She was well made
round as a ball and so wrinkled and porous as to make her surface area
enormous
and bursting with Protein As. She was beautiful.
She, our TOYOPEARL, had
but one dream,
him, a monoclonal antibody.
That would be the ultimate. To bind with him and never ever let him go.
And many other TOYOPEARLs thought the same as she did.
One day it happened. A flood of feedstock flushed over all the TOYOPEARLs
endotoxins, DNA and host cell proteins
and the terrifically well built antibodies were swimming everywhere.
Would she managed to find him
in all of this confusion?
All of a sudden
he swam in front of her... Her monoclonal antibody,
well built and with the full works. A dream antibody...
And she was not alone
All the TOYOPEARLs Protein A found their dream antibodies and the result
was a wild frenzy of meeting up with one another and
combining. It was wonderful...
Just them and their antibodies...
But then it was all over
an acidic buffer gushed over all the lovers. They could no longer be together
The acid was too strong! It tore him away from her!
She called after him:
"Now, you have to save the world!". He called back: "Be prepare, something like me
will come again and again!"
It was all so quick,
so clean...
Peace was restored in the TOYOPEARLs world.
Quietly she called out:
"Hello, are you all still there?"
Yes, all Protein As were still there. And her friends also recognize that all
their Protein As were all still there!
And so they began to dream again...
The TOYOPEARLs
from Tosoh