Tip:
Highlight text to annotate it
X
in my lap are mostly interested in complex
cell
questions are how this complex theorize and its remarkable that twists
all that he's a price that we have in our jeanne on that we can
development function
find the organism that we are interested in c l_ against is
relatively simple
and has all the complexity on the other hand that we humans has and it's an
amazing model for human biology as well as disease i study the nervous system
and a sizable and i'm most interested in
the developments in their system with particular emphasis on glial cells
but i'm also interested in how clear talked to neurons in the context of
development disease sophisticates counter as he did talk to one of your
involvement
and also
after this ten percent one injury nervous system how accents fall apart
singleton glia
that there's danger and how it how
good clearly clear that a brief break
why work again now i hear you mass
are studying developmental biology primarily
and i use a c l_ against as a model system states developmental genetics
perspective
physiology
regulation
we studied a tougher to which means sell feed
all cells use pathogen
and and it's important for the removal
of what may be considered that material importance about offer g
to human diseases is very clear
foliage associated
supporters have links to the facts
so those diseases
disliked cancer in order to correction
my lab is interested in
are very fundamental questions about how
gene expression
regulated
carrying
lifetime of margins and that also
trans generation
and in particular powell
epigenetic system called and
uh... control gene expression
or
one remain advantages outstanding invertebrate is that is the quickness
that we can uncover new phenomenon the ability to spot something unexpected and
follow up and uncover
those unexpected and new phenomena
arms is one of their great advantages of the inverter persistent almost always
observations
and discoveries from the uh...
forgetting invertebrates criminal system applies
converter protest the reason invertebrates artery system one of the
reasons is because you can answer questions about um... one-tenth to one
fifty if you know in time
uh... how does selects talked to sell why did you can in a memo
and then you can expect in most cases but that mechanisms anti-cancer
invertebrates have contributed in many fundamentalist in our science and the
main reasons you can do that in you can be really nice work and there is the
ability uniquely identify specific sells over and over we would
have the human genome sequences c elegance have not been sequence and that
cedras came out in december nineteen ninety
and so all the technologies that have been developed for invertebrates for
genome sequencing on standards you don't have been started and pioneers in at
simpler organisms such as c elegance
also see others has been shown to be instrumental in understanding human
disease and many basic side of the processes including programmed cell
death
back cancer and many others most of the genes that we uh... no reported to
disease were originally discovered
using genetic approaches immortal organisms
whether it's cancer or nora degeneration use model organisms
to study she's contribute to the system here despite that
worms
were relieved
school system no one had ever introduced
transgene into vietnam war
and i just thought this system or concept of being jeans back wasn't such
fundamental importance chin
being able to understand
biology organism obviously it's it's had
a lot of really interesting little secrets
but it was keeping from us
began to learn
the your sins
i was really encourage young scientists specially student starting out too
to consider working on invertebrates system because
uh... you could do experiments quickly and learn something new quickly you
can't do cara conduct experiments specially for genetics
uh... with very little cost
and
but at the same time pose really knew him before she was about living
organisms we are at a very exciting time right now because we have still so much
simpler now with the advance of
and electric techniques and you know what proaches now we're really active
costs about three years old to freestanding really understanding
add the word as a quote unquote system
my advice to young investigator's
but it's the folder institute to find the best system studied the problems
that they're interested
and then once they make it interesting observations that may go against other
polls people probably for facts
follow those observations tested rigorously
and model systems
discussion for businesses you can
move your research forward much more rapidly in a model system
and island and yet you're studying questions that are
monthly fundamental org
uh... new should work on whatever financing
is going to be
the bass one
to solve the question that you're interested in we can use so much now so
could be in interest that i think
for many many many years are going to be leading the way planet
and