James rothman

When I was a college student at Yale, I was studying physics and mathematics and was absolutely intent on becoming a theoretical physicist.

In the earlier years when I started this project at Stanford University, everyone told me it was nuts to go and try to reproduce the mysterious complexities that occur in a whole cell.

The truth is that anyone, almost anyone, who receives the Nobel Prize has some indirect knowledge of one sort or another that they may be a candidate.

I had five years of failure, really, before I had the first initial sign of success.

I became aware of the very complex internal organization in a cell from the basic science classes, and it made me think about how all that could work. It seemed like a great mystery, especially how...

I started taking a basic biology course, and I really loved it. I started asking research questions incessantly. I was drawn very quickly to biology.

I might have been just as happy to have been a practicing primary-care doctor. But as a medical student, I had interacted with patients suffering from neurodegeneration or acute clinical...

As physics students, we are taught that physicists are smart, that chemists are moderately acceptable, and that biologists are certainly not very intelligent. So I wasn't inclined to take a biology...

One of the major lessons in all of biochemistry, cell biology and molecular medicine is that when proteins operate at the sub cellular level, they behave in a certain way as if they're mechanical...