Tip:
Highlight text to annotate it
X
Lithium has been around since nineteen forty-nine. It's the best medicine
to use for treating bipolar disorder. It has also
been -- it is also potentially a window into
into how the illness unfolds in the brain, so
it has been known for about twenty years now that lithium works
on the myo-inositol pathway
in neurons and
it remains, it's still not entirely clear if that is
the main mechanism of action.
There's now another hypothesis that lithium may work in part
through the wnt signaling pathway.
That has led a number of groups to try to understand better whether
those two pathways are key to the illness. Our group actually just
published a paper this month and
archives of general psychiatry showing that
when signaling genes may be implicated bipolar disorder.