She’s the fifth highest-paid actress in Hollywood, with a successful TV series (Grey’s Anatomy) and two blockbuster romcoms (Knocked Up and 27 Dresses) topping her CV. She famously described Knocked Up as ‘sexist, painting the women as shrews’, went through heavy-handed and very public salary negotiations at Grey’s and withdrew from last year’s Emmy race because she didn’t feel she was given the material to warrant a nomination. In a (male-dominated) business where diplomacy counts for more than honesty, an actress saying what she actually thinks upsets the status quo.