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If everybody had Neil Garg Across the U.S.A.
Then everybody'd be ace-in' like all our super TA's
We'd master EAS reactions, Retrosynthesis too
We won't forget about alkenes Acing 14-D
Oxymercuration/Reduction (this side, that side, which attack?)
follows Markovie's rule (H: less substituted side)
Hydroboration/Oxidation (H and OH added 'syn') goes through transition state (don't forget, repeat this twice)
In some alkyne reactions (H, OH as a result)
Enols tautomerize (Neil's fav thing to say)
Everybody's gonna ace it Acing 14-D
Friedel-Crafts Acylation We need acid chloride
We get a product like this one We can't wait for June
We'll all be gone for the summer So now we'll study all day
Tell the teachers we're ace-in' Acing 14-D
EAS makes three substrates (ortho, meta, para, check!)
From two substituents (that affect the regio) Electron donating helps this (weak and strong activators)
withdrawing groups don't (weak and strong deactivators)
Look! Cleminson Reduction (Garg's cool trick he showed in class)
Use Zinc Amalgam (to change the regio)
Everybody's gonna ace it Acing 14-D