Highlight text to annotate itX
I think that for fine lines and very early wrinkles, there is no question
that the topicals such as the retinoids do encourage collagen production.
They encourage the production of the ground substance in the skin that makes
that thickens up the skin, making these wrinkles less voliminous, less obvious.
So, the gold standards, I suppose are the retinoids. The Retin-A, The Tazarotenes are these prescription drugs--
do show evidence to be effective. The downside is that they are acids and they are potentially irritating.
The retinoids are naturally occuring. Many of them, the tretinoins and Retin-a is something that we see naturally.
They also-the retinoids also appear in over the counter products.
There's retinol, which is commonly used, is converted into this all-trans-retinoic acid
which is the biologically active part of the cascade, and it for sure, has benefits.
One of the problems, I think with the over the counter products is that the concentration is very low
because these are essentially irritating products. You can't have a mass marketing or mass product available
that's irritating so concentrations are low, but they do show some slight benefits, no questions about it.