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HelpHippo: Better than learning from Wikipedia
Our previous tutorial provided a mnemonic to learn the substrates of the citric acid
cycle.
“City Access is the only key to suck a sucky few more orphan cities.” (Pause 2,3,4)
This tutorial explains how to “guess” the enzyme name
based on the name of the substrate that is near that enzyme.
We will do this in four parts:
Part One: You “make” citrate (of the citric acid cycle) with citrate “synthase.”
Part Two: The next two do two.
This means that the next two enzymes do two steps each.
“Aconitase” does two steps: it (first) makes and (second) breaks cis-aconitate
So from the mnemonic “city access is the key to” has aconitase 1) before and 2) after
“access.”
Next, isocitrate dehydrogenase is the second enzyme that does two steps:
Like the remainder of the enzymes, isocitrate dehydrogenase is named after
the first thing before its first arrow, isocitrate.
So this enzyme is “is the, only, key to”
Part Three: Names before the arrow.
Now it's easier: the rest of the steps are named based on “what is” before the arrow.
What enzyme does this step? Before the arrow is “Isocitrate” so the
Bonus section: Energy making: “Few cites access no energy.” These 3
steps do not make any energy.
“Is the” “Key to” suck-E” “malice” dehydrogenase?
Yes! And most of these 4 dehydrogenases make an NADH, which eventually becomes 2.5 ATP.
Except for the sucky dehydrogenase, which is sucky because it only makes 1.5 ATP,
because it suckily only makes “F” ADH.
Luckily, the Suc-A synthetase makes one ATP equivelent, so the two suck steps combined
make as mch energy as the regular dehydrogenases.
Pause and review (2,34)
Our next tutorial in our biochemistry playlist will cover more cellular metabolism details.
And visit helphippo.com for more tutorial videos and flashcards.
HelpHippo: Better than learning from Wikipedia