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\f0\fs24 \cf0 In terms of signs or symptoms for patients with neuroendocrine tumors, it
depends to some degree on where the neuroendocrine tumor originated and whether or not it is
a functional neuroendocrine tumor. Some neuroendocrine tumors produce factors that have an effect
on the body like hormones, like insulin and a patient with an insulin producing neuroendocrine
tumor can develop very low glucose levels and symptoms associated with that, dizziness,
memory loss, confusion. Other neuroendocrine tumors can produce substances like catecholamine
or adrenaline, epinephrine or norepinephrine, which can raise someone's blood pressure level
and they could have rapid heart rate or very high blood pressure. Other neuroendocrine
tumors are silent in that they don't produce these hormones and may not be detected until
they get large enough to cause some sort of a mass effect like an obstruction of the gastrointestinal
tract or pain associated with the growth of the tumor, say in the pancreas or another
organ like that.}