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There we go... Ok, great. Ah, so here. I'm putting this online. YouTube here I come...
Oh histone, histone, How was I supposed to know
That you were acetylated?
Oh histone, histone, We tried to connect, although...
Our charge was unrelated.
Show me how you changed your lysine.
Tell me, histone, 'cause I need to know now—oh, because...
Polymerase is transcribing me! And I must confess I want to be
Differently charged with opposite signs— let's intertwine!
Wrapped around you two more times!
Oh baby, inhibiting like that My genes, they start to unwrap—
the TFs, DNase, reading the genes of my body.
I'm on tonight. You know my genes don't lie
and they're starting to regulate: Activation, decondensation,
Don't you see this upregulation?!
You know I'm on tonight, and my genes don't lie
and they're starting to regulate...
To the left, to the left... To the left, to the left...
DNA wraps the histone complex to the left. In the nucleosome—that's my stuff.
What'cha doing to my N-terminus?
You must not know about me. You must not know about me.
I can change my residue in a minute; Acetyl CoA, I'm gonna get it, baby.
You must not know about me. You must not know about me.
Get another binding site in a second, So make sure that you promptly get to thinking:
I'm acetylatable.
So make sure that you get to thinking: I'm acetylatable.