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The reprogramming of stem cells for oncologic
neurodegenerative
and autoimmune diseases
with the participation of Brachydanio Rerio as "Zebrafish"
Voice: Manuela Parodi
Directed by Cosimo Bruzzese
Music by Mike Samaniego
Hi! My name is Brachydanio Rerio, aka Zebrafish
I am here to talk about REDONDA project
REDONDA is a non-profit association supporting research on
the reprogramming of stem cells
the future of oncologic and neurodegenerative treatments
What do I have to do with stem cells??
Some years ago, Pier Mario Biava
an Italian researcher
found out that in my embryos there is a series of substances
very useful for humans
because of their ability to regulate the behaviour of stem cells
Since Pier Mario and I met, 10 years ago
amazing results were achieved
Which results? Pier Mario, please tell them!
Yes, it's true
It is a long time since I started studying your embryos
because I realized that during the embryonal development
we can find a series of sbustances able to stop tumoral growth
Suddenly
I started thinking of tumoral cells as altered stem cells
which instead of developing in a regular way
loose the right path
and continue multiplicating with no order
so I decided to verify if
using those factors able to regulate and differentiate normal stem cells
it was possible to slow or stop tumoral growth
Well, experiments demonstrated that it is possible
and that cancer stem cells
can be considered as altered stem cells
which are responsible for tumor malignancy
These concepts are now approved by the international scientific community
and all the world now considers that
cancer malignancy is caused by the presence of mutated stem cells
These cells are particularly resistent to traditional therapies (chemo and radio)
this is why they are responsible for tumor malignancy
These new regulating and differentiating therapies
are able to reprogram cancer stem cells
and probably to win cancer once and for all
Also neurodegenerative diseases like lateral amyotrophic sclerosis
or Parkinson and Alzheimer disease
are potentially treatble with these principles.
Yes, of course, it is demonstrated that these principles
are active and effective in neurdegenerative diseases
because thay have neuroprotective properties
The problem we face now is that for every single disease
specific factors are required
so that we imagine to reach an almost individual therapy
for each patient
We face the same problem with cancer
tumors are different among themselves
and each one must be treated in different ways
a general therapy does not exist
stem cells differentiating factors
must be adapted to every patient, tumor, pathology
This is the future in front of us and we need to go there
we have it clear
What we need now is to find resources to go ahead
Got it? This is the reason why REDONDA is important
REDONDA works to finance such research
and needs also your support
on www.redonda.it
you will find that the cure for several diseases
with the reprogramming of stem cells
is already possible today
but there's still much to do
DO YOUR PART ! ! !
After intial skepticism, Dr Biava's research
is now shared by the scientific community
and thousands of independent researches in the world
confirmed the possibility of new therapies
starting from stem cells reprogramming factors
Unfortunately
these therapies don't use chemical synthesis
so that they don't match pharmaceutical business interests
currently the only source of financing for such research
This is why REDONDA
- which is composed by scientists and patients who had benefit from these therapies -
decided to support research
on the reprogramming of stem cells.
Support REDONDA
to strenghten research
redonda.onlus@gmail.com