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Hey there chemies
Whatchya doing?
Want to take a break?
But final’s coming up
We’ve got no time to go and play
Problem Sets 1, 2, and 3
Are all that I can do
Dude, this retrosynthesis
It’s killing me, too!
That cyclohexene
And all those dienes
So confused, I give up too
Let’s have some fun today
Wait a second
Is that Vollhardt
Watching us right now?
Oh em gee
I think you’re right
That’s creeping me out
So let’s review some chemistry
And hope that he will leave
There are so many things to know
Let’s start from day 1!
SN1
SN2
Latter has a back-side attack
Invert the product
In a stereochem change
E1
And E2
Don’t forget to deprotonate
Dissociate
Leave the LG to its fate
Eh-eh-eh-eh-eh-eh-eh
All of this chemistry-y-y-y-y-y-y
Just go away-y-y-y-y-y-y
Too much chemistry-y-y-y-y-y-y
Can try all you want but OH is not
A very successful leaving group
Unless you try
Adding Tosylate
Or inorganic molecules
Can try all you want but OH is not
A very successful leaving group
Unless you try
Adding HBr
You’re not gonna make it leave at all!
Chem, the way you blowing up my mind
Is getting me so worked up
Heated like Diels Alder
Man, I need some water
I should’ve never left my dorm
There’s too much to remember
The clock is ticking faster
I need to get some answers
Dealing with epoxides
We will break them open
In acid or in base, we will relieve the ring strain
We want to avoid primary carbocations
They are woefully unstable
So don’t attempt
Son
Epoxidation
MCPBA
Single step, SYN oxygens
Dichloromethane
Come to me
I’ll help you
Solve all these tough reactions
I hold the secrets to passing OChem
Midterm 1
Midterm 2
I can help you get that cape
Don’t run away ):
There is no easy escape
Stop talking
Stop talking
I don’t wanna think anymore
Need activators or
Catalysts for sure
OH
OMe
Are stronger than alkyl groups
They speed up EAS
And donate electrons
Eh-eh-eh-eh-eh-eh
All of this chemistry-y-y-y-y-y-y
Just go away-y-y-y-y-y-y
Too much chemistry-y-y-y-y-y-y
Can attack alkenes or even alkynes
But you must be wary of Marky’s rule
Add H20
The H needs room
So we add it to the less sub’d side
To an alkene add an O
You will need ozonolysis, okay!
Break it in two
Form two carbonyls
And reduce to make some alcohol
O-Chemistry
O-O-O-Chemistry
Figured out all the parts
Now we’re done from the start
Guess we’re not gonna see
Vollhardt no more
O-Chemistry
O-O-O-Chemistry
With Neil as our guide
There’s no need to cry
And we’re totally gonna ace that test!