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hello i'm george colberg executive chairman and co-founder of kalos
therapeutics
i'd like to introduce you to our story today
let's start with our team
you'll see we have gmail artists are chief medical officer
jay was one of the first engaged in the high tech and i'm sure you're familiar
with how successful they become
she was a rapid riser through
upjohn and has been at the end other biomedical companies like by a gene
intrusion which were also very successful
michael kozlowski is our chief scientific officer
mike gladden lead optimization adviser and his bell medical experience
kissinger on intelli very successful companies
if you take a second here's a look at our scientific advisory board
were led by doctor daniel von hoff you probably have seen gan on t_v_ with
stand up to cancer
began as one of the hardest working on college just in america i'm one of the
brightest
he's developed an incredible array of drugs and he still sees patients he
loves his patients and takes great care of them
daniel understands how to work with the f_d_a_ and the regulatory people
to allow drugs to be developed a new areas password kilos needed
we also have dr marc garnick
work now teaches at harvard because he's recently sold his company prices two g s
k
marc was one of the first ten days to develop a peptide in cancer
and canvases of peptide
story
you'll see doctor patrice where you know who has international arnelle mister
chief medical officer
inquisitive mind when it comes to developing new drugs
the chaos approach is different worse hydrostatic therapeutic
take time to slow the cell proliferation down looking at an opportunity to use
peptides of circulating your body
all the time
and resend a therapeutic levels to treat cancer
no chemotherapy no side effects no radiation
a completely new way to treat patients the way they deserve to be treated
you may know a little bit about paying create cancer that's that when you see
on t_v_
the doctor looks at you and says go home and get your paperwork in order you have
cancer
less than five percent of pain create cancer patients survive for five years
every year forty three thousand people are diagnosed with pancreatic cancer
thirty thousand those people will succumb that year
to cancer
median survival time sixteen weeks
this is an incredibly virulent disease
currently treated with chemotherapy and a combination of monoclonal antibodies
and surgery
the outcomes are very tough on patients
are drug
is developed in made in the heart it's an indicted as peptide we have an
opportunity to treat patients better
in a less invasive way
and providing improve quality of life for them
as well as shrinking tumors
let me tell you a little bit more about how we work
it chill naturally peptide is the family of peptides
we are working with
game they're made in the heart
there also made in your kidneys and your shams
they certainly throughout the body but what we're doing is leverage in nature
we take with these peptides were designed to do
control hemodynamics
and hyper cell proliferation
by cancer
cells growing too quickly
and when you have adult cancers and you can have assignees and organ failure
that caused increasing hemodynamic pressure we can control that by raising
these natural
peptides ANP atrial natriuretic peptide
the therapeutic levels in your body using the sign of static approach as
opposed to chemotherapy or radiation
much friendlier on the patient
better outcomes
progress to date
we've taken the natural peptide and shortened it from modern twenty-six
amino acids two thirty seven amino acids we've had clinical experience this drug
has actually been in patients an investigator a handy
no side effects and good outcomes
we know we're safe
we know where last toxic and we can change the way patients are treated
why is a set of static approach important
most people think of cancer patients amie ciated
their hair is gone
there's suffering with sores and pain
that's the effects of the chemotherapy
the cancer
by using a set of static were able to like turning down the thermostat in your
house
reduce the cellular activity controlled so that you may die with your cancer but
not from your cancer
and you'll have a better quality of life as we treat you with these therapeutics
as opposed to those that are on the market now the chemotherapy it's
and targeted therapies
we also work well with those and we've done clinical studies
to see how we would work with some of the standards of care on the market
will be a good fit
the n_c_i_ did a study saying if you were cancer drug works in one type of
cancer you really don't have any truck
we've tested are therapeutic
in nine different cell lines and labs all around the world
and we've proven that we work on a number of cancerous breast cancer lung
cancer as well as pain critical very membrane
some of the most virulent cancers out there
were specially effective in
packed our recent
studies have proven something that you'll find very interesting
our hypothesis was we could put cells into a prolonged on dividing state
that means stopping them from growing
in this first slide you can see that we implanted device in treated the animals
in the study with are peptides for four weeks continuously
and then removed the pump
we want to make sure there were no traces of our medicine
what we have found his these cells as you can see here
did not grow back
we went to a more robust study at one of the best uh... laboratories or sierras
t_v_ to out in arizona with dan van hoff
we increase the tumor britain
two hundred percent
and then try treating those with our side of static
approach to treating cancer
immuno want were every bit as affective
as the best
pancreatic cancer on the market currently
with none of the side effects we can extend life improve quality of life
and help the patients
get better
again a different way of looking at cancer
side of static therapy as opposed to chemotherapy
the cost of pancreatic cancer is amazing
cost last year one point four billion dollars to treat pain creat cancer
this is an expensive disease
these
all diseases art are expensive but pancreatic cancer
it mutates quickly it kills you quickly
sold a physicians have to try cocktails combinations of drugs
different ways of approaching this
and it's going to continue to get more expensive as you see
twenty twenty
the cost will be one point eight billion dollars this is a huge market
and at some unmet need
the patients don't get care that really makes a difference
or that helps them and we can change that
we all have prices are ahead
it's hard to imagine that payers have limits
there what they'll pay four to treat patients
but they do
there in business and we understand that
it cost about fifty to a hundred thousand dollars by the year for what's
called
why algae
your life gained
and that's that's amazing that
they can tell you if it's more than fifty runner thousand dollars a year
payers are going to pay it
four that their pay um... a retail coercive some of the more exotic
effective drugs can cost up to a half billion dollars a year
patients are paying
three thousand ten thousand dollars a month out of pocket plus our coverage
the change the way they get
reimbursed for these drugs so that doctors have risk this is an an
incredible burden on the health care system
we have a better approach
we've reduced the size of our peptides
from that one hundred and twenty six original amino acid down to thirty seven
in the process of drug
uh... optimization we now we're down to eight amino acids it's very safe it's
easy to manufacture very stable
it gives us a new way to treat patients instead of shooting
in the chemotherapy and share for nine hours you at the time
we can do an injection in your doctor can see you on a weekly basis
to make sure you're complying progressing and feeling better
is a broad market out there
we are specially effective in the virulent cancers pancreatic algerian
because there's a higher receptor factor
for our particular peptide
but we work well in breast cancer
i don't know if you know what but there was recently a retrospective study
released to the public says
most of the standard of care the emphasized claims
not only don't treat the tumor affectively
but they cost
cardiac in salzburg cytotoxicity and means you didn't get any benefit of the
drug you knew me suffer heart damage
that's an incredible risk and we feel because our peptides are manufactured in
the heart
that we can help eliminate that risk to patients and treat there was some
populations like
topo choosing triple negatives
the way they deserve to be treated in a more humane manner
and make their life better
ovarian cancer is another unmet medical need and uh... median survival time of
four point seven years
if you are young woman and you have a very in cancer
you get
radiation
you get chemotherapy needed surgery
but you don't get to have a family
because were cited a static
we believe the integrity of your ability to have a family is very very important
by treating this disease in a manner that will shrink the tumors
without sacrificing your ability to have a family
we believe that's very important and again
awaited changed
the weight patients are treated
which is what keyless believes in
to kill solution starts here most of you are used to looking at
patients have had chemo therapy
those cancer patients are may she did
and in suffering in incredible pain
when you don't realize in these abdominal cancers look at this line
this is a patient that has
abdominal cancer
they have suffered organ failure
bloating assignees
incredible pain they want to go out they feel freakish
there won't be seen looking like this
we've proven
in with our clinical experience
that we can increase nietzsche recess and i recess for a five-fold
tailoring this targeted approach
for patients
we can help reduce
this swelling that comes with organ failure in assignees that's gonna reduce
pain that's going priest quality of life
it's going to extend life because you you can have your appetite back
you're gonna feel better you'd be more active so we don't just treat the cancer
we treat the entire patient
that's what we believe in a careless
making a difference
changing the quality of life improving health care
and more economic mia
thanks for spending a few minutes with me and caleb's
remember were assigned a static
were less toxic
were safer
and we can improve the quality of your life today