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My name is Marcus Gidekull and I am 18 years old.
INTERVIEWER: How has it been to able to work in a real labratory for the last two days?
Very interesting. Just were I work, they grow cells so it's really imporant to have sterile enviroment.
That means that everything is being steralized all the time. As soon as you are going to use e.g.
a bottle, you steralize it and then you steralize your hands again.
It's really important to make sure there isn't going to be a bacterial growth
INTERVIEWER: So, Marcus, tell us what you have done during your mentorship today.
I was at the labratory today, and I work with a group of receptors named frizzled.
And right now we're working with a special receptor in this group called frizzled 6.
We want to investigate what happens when a ligand binds to this receptor.
That is not very easy but what you'll do, is that you make the receptor light up by binding a
protein that will light and then you'll bleach a small square on the cell membrane so that all
frizzled will light up except a little square that will become "grey".
And because the frizzleds have free mobility over the cell membrane, the grey frizzled will be
will eventually be equally sqattered. You can measure the amount of time this will take for
frizzled to be equally scattered. And then you'll try when a ligand is binded. This makes frizzled
heavier. As frizzleds become heavier, you can imagine that it will be more difficult for the
frizzleds to be able to move in the membrane. But the interesting thing was when we binded
this ligand to frizzled, it became lighter. This indicates that something is released within
the membrane. And what we think is being released is a protein called Dishevelled.
So this strengthen the theory they've had earlier.